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(Chest. 2004;125:1913-1919.)
© 2004 American College of Chest Physicians

Empiric Therapy of Community-Acquired Pneumonia*

Guidelines for the Perplexed?

Burke A. Cunha, MD

* From the Infectious Disease Division, Winthrop-University Hospital, Mineola, NY; and the State University of New York School of Medicine, Stony Brook, NY.

Correspondence to: Burke A. Cunha, MD, Chief, Infectious Disease Division, Winthrop-University Hospital, Mineola, NY 11501

This article discusses the key clinical aspects of empiric therapy of community-acquired pneumonia (CAP). Antibiotic selection, severity of CAP, single vs multiple pathogens, pharmacokinetic considerations, antibiotic resistance, IV vs oral antibiotic therapy for CAP, oral therapy for non-ICU hospitalized patients with CAP, ß-lactams, macrolides, ketolides, doxycycline, respiratory quinolones, and pharmacoeconomic implications are discussed.

Key Words: community-acquired pneumonia • community-acquired pneumonia antibiotic guidelines • doxycyline • IV to po switch therapy • macrolides/ketolides • natural/acquired antibiotic resistance • oral antibiotic therapy • respiratory quinolones






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