Chest Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via ISI Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gami, A. S.
Right arrow Articles by Somers, V. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gami, A. S.
Right arrow Articles by Somers, V. K.
(Chest. 2004;125:2097-2100.)
© 2004 American College of Chest Physicians

Cardiac Troponin T in Obstructive Sleep Apnea

Apoor S. Gami, MD; Anna Svatikova, BA; Robert Wolk, MD, PhD; Eric J. Olson, MD, FCCP; Carolyn J. Duenwald, BS; Allan S. Jaffe, MD and Virend K. Somers, MD, PhD

* From the Division of Cardiovascular Diseases (Drs. Gami, Wolk, Somers, and Ms. Svatikova), Cardiovascular Physiology Laboratory (Ms. Duenwald), Division of Pulmonary and Critical Care Medicine (Dr. Olson), Department of Laboratory Medicine and Pathology (Dr. Jaffe), Mayo Clinic and Foundation; Rochester, MN.

Correspondence to: Virend K. Somers, MD, PhD, Mayo Clinic, 200 First St SW, Rochester, MN 55905; e-mail: somers.virend{at}mayo.edu

Study objectives: Obstructive sleep apnea (OSA) is associated with nocturnal angina and ST-segment depression, which are relieved by treatment with continuous positive airway pressure (CPAP). We tested the hypothesis that severe nocturnal hypoxia in patients with OSA causes myocyte necrosis as evidenced by increases in cardiac troponin T.

Design: Prospective cohort study.

Setting: Cardiovascular physiology and sleep research laboratory.

Participants: Fifteen male volunteers with coronary artery disease (CAD) and moderate or severe OSA (apnea-hypopnea index [AHI] > 15).

Measurements and results: Polysomnography and measurement of serum cardiac troponin T before sleep, after 4 h of untreated OSA, and in the morning after 4 h of treatment with CPAP. The mean AHI for the group was 41 (SD 16), and the mean oxygen saturation nadir during sleep was 83% (SD 8%). All measurements of cardiac troponin T were < 0.010 ng/mL.

Conclusions: Despite the fact that some patients with OSA may experience nocturnal ischemia, this study shows that patients with severe OSA and coexisting CAD do not have nightly episodes of myocardial injury detectable by the current-generation cardiac troponin T assay.

Key Words: biomarker • coronary artery disease • obstructive sleep apnea • sleep-disordered breathing • troponin






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the American College of Chest Physicians.