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(Chest. 2004;126:11S-13S.)
© 2004 American College of Chest Physicians

Methodology and Grading for Pulmonary Hypertension Evidence Review and Guideline Development*

Douglas C. McCrory, MD, MHS and Sandra Zelman Lewis, PhD

* From the Department of Medicine and the Center for Clinical Health Policy Research (Dr. McCrory), Duke University Medical Center, Department of Veterans Affairs Medical Center, Durham, NC; and American College of Chest Physicians (Dr. Lewis), Northbrook, IL.

Correspondence to: Douglas McCrory, MD, MHS, Duke Center for Clinical Health Policy Research 2200 W. Main St, Suite 220, Durham, NC 27705; e-mail: douglas.mccrory{at}duke.edu

The American College of Chest Physicians assembled a multidisciplinary, geographically diverse panel of experts in the treatment of pulmonary hypertension to develop clinically relevant practice guidelines for the diagnosis and treatment of pulmonary hypertension in its many variations. That group of experts produced recommendations covering five topic areas, each related to a distinct set of patient-management decisions. This article describes the approach used to develop the guidelines, including identifying, evaluating, and synthesizing the evidence, assessing the strength of evidence pertinent to individual guidelines, and grading guideline recommendations.

Key Words: clinical practice guidelines • evidence-based medicine • pulmonary hypertension




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