Chest ACCP Career Connection
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (18)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Franklin, P. J.
Right arrow Articles by Turner, S. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Franklin, P. J.
Right arrow Articles by Turner, S. W.
(Chest. 2004;126:1540-1545.)
© 2004 American College of Chest Physicians

Measuring Exhaled Nitric Oxide Levels in Adults*

The Importance of Atopy and Airway Responsiveness

Peter J. Franklin, PhD; Stephen M. Stick, PhD; Peter N. Le Souëf, MD; Jon G. Ayres, MD and Stephen W. Turner, MD

* From the Department of Respiratory Medicine (Dr. Stick) and School of Paediatrics and Child Health (Drs. Turner, Souëf, and Franklin), Princess Margaret Hospital for Children, Perth, Australia; and Department of Environmental and Occupational Medicine (Professor Ayres), University of Aberdeen, Scotland.

Correspondence to: Stephen W. Turner, MD, School of Medicine, Department of Child Health, Royal Aberdeen Children’s Hospital, Foresterhill, Aberdeen, AB25 2ZG; e-mail s.w.turner{at}abdn.ac.uk

Background: Raised exhaled nitric oxide (FENO) levels have been associated with asthma. However, we have found that in children, FENO was increased in atopic children with increased airway responsiveness (AR), and this was independent of a diagnosis of asthma.

Study objectives: The current study was designed to test the hypothesis that in adults there is no association between FENO and asthma after controlling for atopy and AR.

Measurements: One hundred fifteen adults (77 women; mean age, 41 years) underwent an assessment that included FENO measurements, spirometry, skin-prick testing, blood eosinophil count, and inhaled histamine challenge (results are expressed as a dose-response slope [DRS]).

Results: When only atopic individuals were considered (n = 73), FENO was positively associated with the DRS (p = 0.003), male gender (0.02), and negatively associated with current smoking (p = 0.09). Only male gender (p = 0.03) was associated with FENO among nonatopic individuals (n = 36). In multivariate analysis, there was no association between FENO and current asthma, current wheeze, or asthma ever.

Conclusions: We conclude that in adult subjects, elevated FENO measurements are associated with a phenotype characterized by atopy and increased AR regardless of the presence of asthma or asthma-like symptoms.

Key Words: asthma • bronchial hyperreactivity • hypersensitivity • nitric oxide • smoking




This article has been cited by other articles:


Home page
 ChestHome page
A.-C. Olin, A. Rosengren, D. S. Thelle, L. Lissner, B. Bake, and K. Toren
Height, age, and atopy are associated with fraction of exhaled nitric oxide in a large adult general population sample.
Chest, November 1, 2006; 130(5): 1319 - 1325.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005
Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 912 - 930.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the American College of Chest Physicians.