HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Guest Access | Sign In via User Name/Password

This Article Full Text Free Full Text (PDF) Free Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Personal Article Archive Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sackner, M. A. Articles by Adams, J. A. Search for Related Content PubMed PubMed Citation Articles by Sackner, M. A. Articles by Adams, J. A.

Nitric Oxide Is Released Into Circulation With Whole-Body, Periodic Acceleration^*

^* From the Division of Pulmonary Disease and Critical Medicine (Dr. Sackner), and Department of Neonatology (Dr. Adams), Mount Sinai Medical Center, Miami Beach; and Non-Invasive Monitoring Systems, Inc. (Ms. Gummels), North Bay Village, FL.

Correspondence to: Marvin A Sackner, MD, FCCP, 300 West Rivo Alto Dr, Miami Beach, FL 33139; e-mail: Artchive{at}msn.com

Study objective: To determine if comfortably applied, whole-body, periodic acceleration releases significant amounts of nitric oxide (NO) into the circulation of healthy subjects and patients with inflammatory diseases.

Materials: Fourteen healthy adults and 40 adult patients with inflammatory diseases underwent single 45-min trials of whole-body, periodic acceleration with a new "passive exercise" device, while an ECG and a digital pulse wave were obtained with a photoelectric-plethysmograph sensor.

Methods: The position of the dicrotic notch from the pulse waveform was computed from the amplitude of the pulse divided by the height of the dicrotic notch above the end-diastolic level (a/b ratio). Increase of the a/b ratio reflects the vasodilator action of NO that causes downward movement of the dicrotic notch in the diastolic limb of the digital pulse, thereby elevating the a/b ratio.

Results: Application of whole-body, periodic acceleration was well tolerated in all participants, and all completed the 45-min treatment. The peak value of the a/b ratio markedly rose during periodic acceleration and returned to baseline during a 5-min recovery period in all healthy subjects and patients with inflammatory diseases.

Conclusions: Whole-body, periodic acceleration increased pulsatile shear stress to the endothelium leading to vasodilatation and a fall in the dicrotic notch, consistent with increased NO bioactivity in every healthy adult and adult patient with inflammatory disease so treated. Therefore, passive exercise using whole-body, periodic acceleration produces an important benefit that occurs with active exercise.

Key Words: dicrotic notch • endothelial nitric oxide synthase • nitric oxide

This article has been cited by other articles:

				W. M. Abraham, A. Ahmed, I. Serebriakov, I. T. Lauredo, J. Bassuk, J. A. Adams, and M. A. Sackner Whole-Body Periodic Acceleration Modifies Experimental Asthma in Sheep Am. J. Respir. Crit. Care Med., October 1, 2006; 174(7): 743 - 752. [Abstract] [Full Text] [PDF]

				M. A. Sackner, E. Gummels, and J. A. Adams Effect of Moderate-Intensity Exercise, Whole-Body Periodic Acceleration, and Passive Cycling on Nitric Oxide Release Into Circulation Chest, October 1, 2005; 128(4): 2794 - 2803. [Abstract] [Full Text] [PDF]