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(Chest. 2005;127:678-681.)
© 2005 American College of Chest Physicians

Severe Autoimmune Hemolytic Anemia Treated by Paralysis, Induced Hypothermia, and Splenic Embolization*

Ronna Campbell, MD, PhD and Paul E. Marik, MD, FCCP

* From the Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.

Correspondence to: Paul Marik, MD, FCCP, Professor of Critical Care and Medicine, Department of Critical Care, University of Pittsburgh, 640A Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261; e-mail: maripe{at}ccm.upmc.edu

Autoimmune hemolytic anemia (AIHA) is the clinical condition in which IgG antibodies bind to RBC surface antigens and initiate RBC destruction via the complement and reticuloendothelial system. AIHA is commonly treated with transfusions, corticosteroids, and splenectomy. We present a case of an adult with life-threatening AIHA secondary to ulcerative colitis emergently managed with neuromuscular paralysis, induced hypothermia, and splenic embolization.

Key Words: autoimmune hemolytic anemia • hypothermia • liver transplantation • splenic embolization • ulcerative colitis






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