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(Chest. 2005;128:370-381.)
© 2005 American College of Chest Physicians

Lung Cancer in Women*

Emerging Differences in Epidemiology, Biology, and Therapy

Leno Thomas, MD; L. Austin Doyle, MD and Martin J. Edelman, MD

* From the University of Maryland Greenebaum Cancer Center, Baltimore, MD.

Correspondence to: Martin J. Edelman, MD, University of Maryland Greenebaum Cancer Center, 22 South Greene St, Baltimore, MD 21201; e-mail: medelman{at}umm.edu

Lung cancer is the major cause of cancer-related death in both men and women in the United States. Emerging evidence indicates that there are differences in the pathogenesis and possibly increased susceptibility to lung cancer in women. In addition, considerable data support small, but important differences favoring women in terms of response to therapy and long-term survival after the diagnosis of lung cancer, regardless of histology or stage. These differences in both biology and outcome will be important considerations in the design of future trials of screening and therapy for lung cancer.

Key Words: DNA repair • estrogen receptor • human papilloma virus • non-small cell lung cancer • sex • small cell lung cancer




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