Chest ACCP Career Connection
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhu, Z.
Right arrow Articles by Light, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhu, Z.
Right arrow Articles by Light, R. W.
(Chest. 2005;128:934-939.)
© 2005 American College of Chest Physicians

Efficacy of Ultrasound in the Diagnosis of Pleurodesis in Rabbits*

Zhiwen Zhu, MD; Edwin Donnelly, MD, PhD, FCCP; Oner Dikensoy, MD; Heather Misra, MD; Semra Bilaceroglu, MD; Kirk B. Lane, PhD and Richard W. Light, MD, FCCP

* From the Division of Allergy, Critical Care, and Pulmonary Disease (Drs. Dikensoy, Misra, Bilaceroglu, Lane, and Light), Vanderbilt University and Saint Thomas Hospital, Nashville, TN; the Department of Radiology and Radiological Sciences (Dr. Donnelly), Vanderbilt University, Nashville, TN; and the Department of Pulmonary and Critical Care Medicine (Dr. Zhu), The First Affiliated Hospital of Zhongshan (Sun Yat-Sen) University, Guangzhou, ROC.

Correspondence to: Richard W. Light, MD, FCCP, Director of Pulmonary Disease Program, Saint Thomas Hospital, 4220 Harding Rd, Nashville, TN 37205; e-mail: rlight98{at}yahoo.com

Introduction: The treatment of recurrent pleural effusion or recurrent pneumothorax frequently involves the creation of a pleurodesis. Ultrasound is being used more frequently to assess the presence of pleural fluid or pneumothorax. With ultrasound, the gliding sign displays the gliding of the visceral pleura over the parietal pleura during respiration. The absence of a gliding sign is indicative of a pneumothorax.

Hypothesis: We hypothesized that the presence of pleurodesis would be indicated by the absence of a gliding sign on ultrasound.

Methods: To create a pleurodesis, a single intrapleural injection of transforming growth factor-ß2 at a dosage of 1.70 µg/kg or doxycycline at a dosage of 10 mg/kg in a volume of 2.0 mL was administered randomly to one side of a New Zealand White rabbit. Prior to death on day 14 after intrapleural injection, all rabbits underwent an ultrasonic examination at three marked sites on each side of the chest. At each site, three ultrasonic features (gliding sign, pleural thickening, and pleural effusion) were evaluated and graded. The gliding sign was graded as follows: 0 = gliding sign definitely present, 1 = gliding sign questionable, 2 = gliding sign absent.

Results: In a preliminary study for developing skill in assessing the gliding sign, the correlation between the gliding sign and the pleurodesis score in 16 rabbits was highly significant (r = 0.568, p = 0.02). In the subsequent main study with 18 additional rabbits, the correlation between the gliding sign score and the pleurodesis score was even better (r = 0.806, p = 0.00009). The gliding sign was definitely present on the noninjected side in all rabbits

Conclusions: The presence of a pleurodesis is indicated by the absence of a pleural guiding sign on ultrasound.

Key Words: gliding sign • pleural effusion • pleurodesis • pneumothorax • ultrasound




This article has been cited by other articles:


Home page
 ChestHome page
O. Dikensoy, Z. Zhu, E. Donnelly, G. T. Stathopoulos, K. B. Lane, and R. W. Light
Combination Therapy With Intrapleural Doxycycline and Talc in Reduced Doses Is Effective in Producing Pleurodesis in Rabbits
Chest, November 1, 2005; 128(5): 3735 - 3742.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the American College of Chest Physicians.