Chest ACCP Member Benefits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Parambil, J. G.
Right arrow Articles by Utz, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parambil, J. G.
Right arrow Articles by Utz, J. P.
(Chest. 2005;128:3678-3680.)
© 2005 American College of Chest Physicians

Alkaptonuria Diagnosed by Flexible Bronchoscopy*

Joseph G. Parambil, MD; Craig E. Daniels, MD; Kenton J. Zehr, MD, FCCP and James P. Utz, MD, FCCP

* From the Division of Pulmonary and Critical Care Medicine (Drs. Parambil, Daniels, and Utz) and Department of Cardiovascular Surgery (Dr. Zehr), Mayo Clinic, Rochester, MN.

Correspondences to: James P. Utz, MD, Division of Pulmonary and Critical Care Medicine, Desk East 18, Mayo Clinic, 200 First St SW, Rochester, MN 55905; e-mail: utz.james{at}mayo.edu

A 68-year-old white man was evaluated for failure to wean from mechanical ventilation after cardiac surgery. Bronchoscopy performed prior to percutaneous dilatational tracheotomy revealed circumferential strikingly dark-colored airways, most prominent in the trachea and mainstem bronchi, extending distally into all airways with overlying desiccated black secretions. Histologic examination of bronchial mucosal biopsy samples and the desiccated secretions showed acute bronchitis and necrotic debris, respectively. This finding and the patient’s history led to testing for plasma homogentisic acid, which was found to be elevated at 12.6 µg/mL, establishing the first diagnosis of alkaptonuria made using flexible bronchoscopy.

Key Words: alkaptonuria • bronchoscopy • homogentisic acid






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the American College of Chest Physicians.