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(Chest. 2005;128:598S-604S.)
© 2005 American College of Chest Physicians

Understanding the Consequences of Transfusion-Related Acute Lung Injury*

Aryeh Shander, MD, FCCP and Mark A. Popovsky, MD

* From the Department of Anesthesiology and Critical Care Medicine (Dr. Shander), Englewood Hospital and Medical Center, Englewood, NJ; and Haemonetics Corporation (Dr. Popovsky), Braintree, MA.

Correspondence to: Aryeh Shander, MD, FCCP, Chief, Department of Anesthesiology and Critical Care Medicine, Medical Director, New Jersey Institute for the Advancement of Bloodless Medicine and Surgery, Englewood Hospital and Medical Center, 350 Engle St, Englewood, NJ 07631; e-mail: aryeh.shander{at}ehmc.com

Although the blood supply has become safer with regard to transmission of infectious agents, attention should continue to focus on understanding and eliminating the other serious risks associated with transfusion. Transfusion-related acute lung injury (TRALI) is one such risk, only recently becoming recognized as an important and potentially preventable clinical syndrome. Strategies for prevention of TRALI, however, must rely on knowledge regarding its etiology and diagnosis, and significant gaps in our understanding of the syndrome currently exist. This review summarizes what is known and unknown about the incidence, severity, etiology, diagnosis, and prevention of TRALI and the potential consequences of these knowledge gaps.

Key Words: diagnosis • etiology • transfusion-related acute lung injury




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