Chest ACCP Education Calendar
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via ISI Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tschopp, O.
Right arrow Articles by Boehler, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tschopp, O.
Right arrow Articles by Boehler, A.
(Chest. 2006;129:1002-1008.)
© 2006 American College of Chest Physicians

Pretransplantation Bone Disease in Patients With Primary Pulmonary Hypertension*

Oliver Tschopp, MD; Christoph Schmid, MD; Rudolf Speich, MD, FCCP; Burkhardt Seifert, MD; Erich W. Russi, MD, FCCP and Annette Boehler, MD, FCCP

* From the Divisions of Endocrinology (Drs. Tschopp and Schmidt) and Pulmonary Medicine (Drs. Speich, Russi, and Boehler), and Department of Biostatistics (Dr. Seifert), University Hospital, CH-8091 Zurich, Switzerland.

Correspondence to: Annette Boehler, MD, FCCP, Division of Pulmonary Medicine, and Lung Transplant Program C HOER 19, University Hospital, CH-8091 Zurich, Switzerland; e-mail: capybara{at}compuserve.com

Abstract

Introduction: Osteoporosis is a common condition in patients with end-stage lung disease, but little attention has been given to bone disease in patients with primary pulmonary hypertension (PPH). The purposes of this study were as follows: (1) to determine the prevalence of osteoporosis in patients with severe PPH before lung transplantation, (2) to investigate whether generally accepted risk factors for osteoporosis would play a role in this special group of patients, and (3) to determine whether there is an association between functional parameters and pretransplantion bone mass.

Design: A retrospective analysis of 18 consecutive patients with PPH accepted for lung transplantation at the University Hospital of Zurich.

Measurements and results: Decreased bone mineral density (BMD) [T score <– 1.0] was found in 11 of 18 patients (61%) at the femoral neck (FN) and 13 of 18 patients (72%) at the lumbar spine (LS). We did not find a significant difference of BMD in a gender- or age-specific manner. Body mass index (BMI) correlated significantly with BMD and T score at the FN and WT. Pulmonary vascular resistance (PVR) was notably linked with BMD at the FN. We found a positive association between walking distance in the 12-min walking test and BMD at the FN and WT.

Conclusions: Low bone density is a very frequent condition in patients with severe PPH. In contrast to the general population, in our study group neither age nor female gender were significantly associated with lower bone mass. Body weight and BMI were highly coupled with BMD. Among the functional parameters, walking distance and PVR were correlated to BMD at the FN. Considering that patients with PPH may have an improved life expectancy in the future, the early diagnosis, prevention, and treatment of osteoporosis should receive high priority.

Key Words: bone mineral density • lung transplantation • osteoporosis • primary pulmonary hypertension






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the American College of Chest Physicians.