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(Chest. 2006;129:853-862.)
© 2006 American College of Chest Physicians

Pulmonary Function and Abdominal Adiposity in the General Population*

Heather M. Ochs-Balcom, PhD; Brydon J.B. Grant, MD; Paola Muti, MD; Christopher T. Sempos, PhD; Jo L. Freudenheim, PhD; Maurizio Trevisan, MD; Patricia A. Cassano, PhD; Licia Iacoviello, PhD and Holger J. Schünemann, MD, PhD

* From the Department of Social and Preventive Medicine (Drs. Ochs-Balcom, Grant, Muti, Sempos, Freudenheim, Trevisan, and Schünemann), School of Public Health and Health Professions, University at Buffalo, Buffalo, NY; the Division of Nutritional Sciences (Dr. Cassano), Cornell University, Ithaca, NY; and the Center for High Technology Research and Education in Biomedical Sciences (Dr. Iacoviello), Catholic University, Campobosso, Italy.

Correspondence to: Holger J. Schünemann, MD, PhD, INFORMA, National Cancer Institute Regina Elena, Rome, Via Elio Chianesi 53, 00144 Rome, Italy; e-mail: schuneh{at}mcmaster.ca

Abstract

Background: The prevalence of obesity is increasing, and there is evidence that obesity, in particular abdominal obesity as a marker of insulin resistance, is negatively associated with pulmonary function. The mechanism for this association and the best marker of abdominal adiposity in relation to pulmonary function is not known.

Study objective: We assessed the association between pulmonary function and weight, body mass index (BMI), waist circumference, waist/hip ratio, and abdominal height as markers of adiposity and body fat distribution. We used multiple linear regression to analyze the association of pulmonary function (ie, FEV1 and FVC) [with maneuvers performed in the sitting position] with overall adiposity markers (ie, weight and BMI) and abdominal adiposity markers, stratified by gender, and adjusted for height, age, race, smoking, and other covariates.

Setting and participants: A random sample of individuals (n = 2,153) from the general population living in western New York state, 35 to 79 years of age.

Results: In women, abdominal height and waist circumference were negatively associated with FEV1 percent predicted, while all five adiposity markers were negatively associated with FVC percent predicted. In men, all overall and abdominal adiposity markers were inversely associated with FEV1 percent predicted and FVC percent predicted.

Conclusion: These results suggest that abdominal adiposity is a better predictor of pulmonary function than weight or BMI, and investigators should consider it when investigating the determinants of pulmonary function.

Key Words: abdominal height • airway obstruction • body mass index • body weight • forced expiratory volume • FVC • obesity






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