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(Chest. 2006;129:947-953.)
© 2006 American College of Chest Physicians

Plasma Adhesion Molecules in Children With Sleep-Disordered Breathing*

Louise M. O’Brien, PhD; Laura D. Serpero, PhD; Riva Tauman, MD and David Gozal, MD, FCCP

* From Kosair Children’s Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics (Drs. O’Brien, Serpero, and Tauman), and Department of Pharmacology and Toxicology (Dr. Gozal), University of Louisville, Louisville, KY.

Correspondence to: David Gozal, MD, FCCP, Kosair Children’s Hospital Research Institute, University of Louisville School of Medicine, 571 S. Preston St, Suite 321, Louisville, KY 40202; e-mail: david.gozal{at}louisville.edu

Abstract

Study objectives: To determine whether childhood sleep-disordered breathing (SDB) is associated with elevated levels of plasma adhesion molecules.

Design: Prospective, observational study.

Setting: Sleep Medicine Center of Kosair Children’s Hospital.

Participants: Thirty-nine children with SDB (apnea-hypopnea index [AHI] > 5/h), 47 children with mild SDB (AHI 1 to 5/h), and 42 healthy control subjects (AHI < 1/h).

Measurements and results: One hundred twenty-eight children underwent a standard polysomnographic assessment with a blood draw the following morning. Plasma levels of CRP and the adhesion molecules intercellular adhesion molecule (ICAM)-1 and P-selectin were measured. No differences were observed in ICAM-1 levels among the groups; however, obese children had higher ICAM-1 levels than nonobese children (425.0 ± 123.0 ng/mL vs 375.6 ± 107.1 ng/mL, p = 0.04) [mean ± SD]. P-selectin levels were significantly higher in the SDB group (84.0 ± 52.2 ng/mL) and the mild SDB group (89.3 ± 49.9 ng/mL) when compared to control subjects (49.5 ± 22.3 ng/mL; p < 0.001 for both groups). Furthermore, P-selectin correlated with AHI (r = 0.32, p < 0.001), respiratory arousal index (r = 0.27, p = 0.002), and nadir of oxygen saturation as measured by pulse oximetry (r = – 0.19, p = 0.038). Plasma CRP levels were found to correlate with P-selectin even after controlling for BMI (r = 0.20, p = 0.05). No correlations were found between CRP and ICAM-1.

Conclusions: Children with SDB have plasma elevations of P-selectin, a marker of platelet activation, lending support to the premise that inflammatory processes are elicited by SDB in children, and may contribute to accelerated risk for cardiovascular morbidity. In contrast, elevations in ICAM-1 are primarily associated with obesity rather than SDB.

Key Words: adhesion molecules • atherosclerosis • sleep-disordered breathing






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