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(Chest. 2006;129:1516-1522.)
© 2006 American College of Chest Physicians

Use of Peak Oxygen Consumption in Predicting Physical Function and Quality of Life in COPD Patients*

Michael J. Berry, PhD; Norman E. Adair, MD and W. Jack Rejeski, PhD

* From the Department of Health and Exercise Science, and Section on Pulmonary and Critical Care Medicine, Department of Medicine, Wake Forest University, Winston-Salem, NC.

Correspondence to: Michael J. Berry, PhD, Department of Health and Exercise Science, PO Box 7868, Wake Forest University, Winston-Salem, NC 27109-7868; e-mail: berry{at}wfu.edu

Abstract

Objective: To determine whether peak oxygen consumption (VO2peak) adds to the power of FEV1 in predicting physical function and quality of life in COPD patients.

Design: Single-center cross-sectional study.

Methods: Subjects included 291 COPD patients who completed pulmonary function testing, a graded exercise test, a 6-min walk, and stair climb test to assess physical function; a questionnaire assessing self-reported physical function; and a disease-specific, health-related quality-of-life questionnaire. Hierarchical multiple regression analysis was used to determine the contribution of VO2peak in predicting physical function and quality of life after accounting for FEV1.

Results: After accounting for FEV1, VO2peak added significantly to the prediction of 6-min walk distance (R2 increased by 0.395 [p < 0.005]); stair climb time (R2 increased by 0.262 [p < 0.005]); self-reported function (R2 increased by 0.109 [p < 0.005]); and health-related quality-of-life domain of mastery (R2 increased by 0.044 [p < 0.005]). Only VO2peak was found to significantly predict the health-related quality-of-life domain of fatigue (R2 = 0.094 [p < 0.005]).

Conclusion: After controlling for FEV1, VO2peak adds significantly to the prediction of physical function and health-related quality-of-life domain of mastery in COPD patients. These results provide additional support for the use of VO2peak in the multidimensional assessment of COPD patients.

Key Words: exercise tests • peak oxygen consumption • pulmonary function tests • quality of life






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