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(Chest. 2006;130:214-217.)
© 2006 American College of Chest Physicians

Reversal of Idiopathic Pulmonary Arterial Hypertension and Allograft Pneumonectomy After Single Lung Transplantation*

Subrato Deb, MD; Joon Yun, MD; Nelson Burton, MD; Edward Omron, MD; John Thurber, MD and Steven D. Nathan, MD, FCCP

* From the Departments of Cardiothoracic Surgery (Drs. Deb and Thurber) and Pulmonary and Critical Care Medicine (Drs. Yun and Omron), National Naval Medical Center, Bethesda, MD; and Inova Heart and Vascular Institute (Drs. Burton and Nathan), Falls Church, VA.

Correspondence to: Steven D. Nathan, MD, FCCP, Heart and Lung Transplant Center, Inova Heart and Vascular Institute, 3300 Gallows Rd, Falls Church, VA 22042; e-mail: steven.nathan{at}inova.com

Abstract

Prior to the advent of effective medical therapies, the only treatment option for patients with idiopathic pulmonary arterial hypertension (IPAH) was lung transplantation. We present the case of a woman who underwent single-lung transplantation for the treatment of IPAH > 10 years ago in whom chronic rejection developed. Despite complete obliteration of the allograft, it was noted that her PA pressure levels had almost normalized. Therefore, an allograft pneumonectomy was performed. To our knowledge, this is the first reported case of the regression of pulmonary vascular disease following lung transplantation with subsequent successful removal of the allograft.

Key Words: graft rejection • hypertension • lung transplantation • pneumonectomy • pulmonary




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D. C. Grinnan, P. Fairman, J. Pinson, and S. D. Nathan
Recurrence of Severe Pulmonary Hypertension Following the Removal of a Lung Allograft
Chest, December 1, 2007; 132(6): 2057 - 2058.
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