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(Chest. 2006;130:879-884.)
© 2006 American College of Chest Physicians

Gene Therapy for Pulmonary Diseases*

Martin Kolb, MD, PhD; Gail Martin, PhD; Maria Medina, PhD; Kjetil Ask, PhD and Jack Gauldie, PhD

* From the Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. None of the authors has a conflict of interest regarding companies/organizations whose products may be discussed in this article.

Correspondence to: Jack Gauldie, PhD, McMaster University, Pathology and Molecular Medicine, 1200 Main St W, Hamilton, ON, Canada L8N 3Z5; e-mail: gauldie{at}mcmaster.ca

Abstract

Gene therapy has not yet met the high expectations of "the early days." However, it is a promising new treatment for lung diseases. Not only single gene disorders such as CF are potential candidates for gene therapy, but also cancer and chronic lung diseases characterized by an imbalance of damaging and protective mechanisms. This review summarizes the recent advances in the development of more efficient gene transfer systems and highlights areas of clinical application of gene therapy.

Key Words: {alpha}1-antitrypsin deficiency • asthma • cystic fibrosis • genetics • lung immunology






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Copyright © 2006 by the American College of Chest Physicians.