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(Chest. 2006;130:896-901.)
© 2006 American College of Chest Physicians

The Relationship Between Migraine and Right-to-Left Shunt*

Fact or Fiction?

Martijn C. Post, MD, PhD and Werner Budts, MD, PhD

* From the Department of Cardiology (Dr. Post), St Antonius Hospital, Nieuwegein, the Netherlands; and Department of Cardiology (Dr. Budts), Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium.

Correspondence to: Martijn C. Post, MD, PhD, Department of Cardiology, St Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, the Netherlands; e-mail: m.post{at}antonius.net

Abstract

The prevalence of a right-to-left shunt, both cardiac and pulmonary, is high in patients with migraines, especially migraine with aura. Percutaneous closure of a right-to-left shunt seems to be associated with a pronounced decrease in the number of migraine attacks or its prevalence. In this review, the relationship between migraine and right-to-left shunting is described by highlighting the different pathophysiologic hypotheses.

Key Words: arteriovenous malformation • atrial septal defect • migraine • patent foramen ovale • shunt






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Copyright © 2006 by the American College of Chest Physicians.