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(Chest. 2007;131:172-179.)
© 2007 American College of Chest Physicians

Uteroglobin-Related Protein 1 and Clara Cell Protein in Induced Sputum of Patients With Asthma and Rhinitis*

Claire de Burbure, MD; Patrizia Pignatti, MD; Massimo Corradi, MD; Mario Malerba, MD; André Clippe, BSc; Xavier Dumont, BSc; Gianna Moscato, MD; Antonio Mutti, MD and Alfred Bernard, PhD

* From the Unit of Industrial Toxicology and Occupational Medicine (Drs. de Burbure, Clippe, Dumont, and Bernard), Faculty of Medicine, Université Catholique de Louvain, Belgium; Allergy and Immunology Unit (Drs. Pignatti and Moscato), Fondazione Salvatore Maugeri, IRCCS, Pavia, Italy; Laboratorio di Tossicologia Industriale (Drs. Corradi and Mutti), Universita degli Studi di Parma, Parma, Italy; and Department of Internal Medicine (Dr. Malerba), University of Brescia, Spedali Civili, Brescia, Italy.

Correspondence to: Alfred Bernard, PhD, Unit of Industrial Toxicology and Occupational Medicine, Université Catholique de Louvain, Clos Chapelle-aux-Champs 30, bte 3054, B-1200 Brussels, Belgium; e-mail: bernard{at}toxi.ucl.ac.be

Abstract

Rationale: Uteroglobin-related protein 1 (UGRP1) and Clara cell protein (CC16), members of the secretoglobin family, increasingly appear to play a role in airway inflammatory response.

Objective: To explore levels of UGRP1 and CC16 in induced sputum of patients with asthma and rhinitis.

Methods: Induced-sputum samples of patients with asthma or rhinitis (n = 32 each; atopic asthma, n = 24; atopic rhinitis, n = 20) and from 19 nonsmoking nonatopic control subjects were analyzed for cytology and levels of UGRP1, CC16, and albumin.

Measurements and main results: Sputum UGRP1 increased in both asthma and rhinitis, most strikingly so in asthma, in which changes were most significant in atopic individuals. By contrast, sputum CC16 did not change significantly in either condition, although it was positively correlated with UGRP1 in patients and control subjects. Changes in sputum UGRP1 in atopic asthma were not linked to permeability changes reflected by increased albumin levels but correlated positively with sputum macrophages and negatively with eosinophils. The observed differences in UGRP1 and CC16 may be linked to different cell populations being responsible for their secretion; UGRP1 is mainly secreted in larger conducting airways, whereas CC16 is mainly secreted by the nasal and peripheral airways epithelium.

Conclusions: The increase in UGRP1 but not of CC16 in asthma and rhinitis suggests that UGRP1 may play a role in these inflammatory diseases.

Key Words: asthma • Clara cell protein • induced sputum • rhinitis • uteroglobin-related protein 1






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