Chest ACCP Education Calendar
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
doi:10.1378/chest.06-2472
(Chest. 2007; 131:870-873)
© 2007 American College of Chest Physicians
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via ISI Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pifferi, M.
Right arrow Articles by Boner, A. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pifferi, M.
Right arrow Articles by Boner, A. L.

Nasal Nitric Oxide in Atypical Primary Ciliary Dyskinesia*

Massimo Pifferi, MD; Davide Caramella, MD; Angela M. Cangiotti, MD; Vincenzo Ragazzo, MD; Pierantonio Macchia, MD and Attilio L. Boner, MD

* From the Departments of Pediatrics (Drs. Pifferi, Ragazzo, and Macchia) and Radiology (Dr. Caramella), University of Pisa, Pisa, Italy; the Electron Microscopy Unit (Dr. Cangiotti), University of Ancona, Ancona, Italy; and the Department of Pediatrics (Dr. Boner), University of Verona, Verona, Italy.

Correspondence to: Massimo Pifferi, MD, University of Pisa, Department of Pediatrics, Via Roma 67, 56122 Pisa, Italy; e-mail: m.pifferi{at}med.unipi.it

Abstract

Background: Atypical cases of primary ciliary dyskinesia (PCD) may present with minimal transmission electron microscopy (TEM) defects. The diagnostic role of nasal nitric oxide (nNO) levels was evaluated in those patients.

Methods: Sixty-four children with recurrent pneumonia were studied with ciliary motion analysis, TEM, and nNO.

Results: Investigations indicated PCD in 12 patients, secondary ciliary dyskinesia (SCD) in 50 patients, and normal results in 2 patients. In 4 of 50 children with SCD, atypical PCD was considered possible. The mean (± SD) nNO was 130 ± 46.95 parts per billion in children affected by PCD, 127.79 ± 68.58 parts per billion in atypical patients, and 760 ± 221 parts per billion in children with SCD. Three to 5 months later, the nNO level was 132.75 ± 55.76 parts per billion in children with atypical disease and 778.00 ± 197 parts per billion in children with SCD.

Conclusion: Low levels of nNO may help to identify patients with atypical PCD.

Key Words: atypical cases • atypical patients • nasal nitric oxide • primary ciliary dyskinesia






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American College of Chest Physicians.