Chest
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
doi:10.1378/chest.06-2017
(Chest. 2007; 131:1479-1485)
© 2007 American College of Chest Physicians
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Siafaka, A.
Right arrow Articles by Nanas, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Siafaka, A.
Right arrow Articles by Nanas, S.

Acute Effects of Smoking on Skeletal Muscle Microcirculation Monitored by Near-Infrared Spectroscopy*

Angeliki Siafaka, MD; Epameinondas Angelopoulos, MD; Konstantinos Kritikos, MD; Magdalini Poriazi, MD; Neofitos Basios, MD; Vasiliki Gerovasili, MD; Antonios Andreou, MD; Charis Roussos, MD, PhD, FCCP and Serafim Nanas, MD

* From the First Critical Care Department, Evangelismos Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Correspondence to: Serafim Nanas, MD, First Critical Care Department, Evangelismos Hospital, National and Kapodistrian University of Athens, Athens, Greece; e-mail: snanas{at}cc.uoa.gr

Abstract

Background: Cigarette smoking predisposes to vascular disease. Our study aimed to assess the acute effects of cigarette smoking on peripheral microcirculation using near-infrared spectroscopy (NIRS) and to compare microcirculatory function of smokers with that of nonsmokers.

Methods: We examined 65 healthy volunteers: 25 smokers (14 men and 11 women; age range, 20 to 27 years) and 40 nonsmokers (31 men and 9 women; age range, 19 to 38 years). Smokers had refrained from smoking for 2 h prior to the examination. Tissue O2 saturation (StO2), defined as the percentage of hemoglobin saturation in the microvasculature compartments, was measured with a probe placed on the thenar muscle. StO2 baseline values were recorded for 5 min. Subsequently, the brachial artery occlusion technique was applied to evaluate microcirculatory function before, during, and after smoking one cigarette.

Results: StO2 before smoking was 85 ± 6% (mean ± SD), not differing significantly between men and women (84.4 ± 6.6% vs 85.6 ± 5.8%, respectively; p = 0.721). StO2 did not change significantly during smoking. O2 consumption rate was significantly greater in women (33.4 ± 6.7 StO2 U/min vs 25.7 ± 7.1 StO2 U/min, p = 0.032) at baseline and throughout the smoking session. O2 consumption rate was reduced during smoking (p < 0.001) and at 5 min after the smoking session. Smoking had a significant effect on vascular reactivity (p = 0.015), with no significant differences between genders. Five minutes after smoking, vascular reactivity had returned to approximately normal levels.

Conclusion: Smoking acutely affects microcirculatory function. NIRS is a noninvasive, operator-independent technique that can document these effects. It seems promising for the prospective evaluation of the effects of long-term exposure to cigarette smoke.

Key Words: microcirculation • near-infrared spectroscopy • smoking • vascular reactivity






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American College of Chest Physicians.