Chest Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
First published online on June 15, 2007
Chest, doi:10.1378/chest.06-3082
doi:10.1378/chest.06-3082
(Chest. 2007; 132:569-574)
© 2007 American College of Chest Physicians
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
chest.06-3082v1
132/2/569    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kaza, V.
Right arrow Articles by Safdar, Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaza, V.
Right arrow Articles by Safdar, Z.

Correlation of Chest Radiograph Pattern With Genotype, Age, and Gender in Adult Cystic Fibrosis*

A Single-Center Study

Vaidehi Kaza, MD; Marcia F. Katz, MD; Suzanne Cumming, RN; Adaani E. Frost, MD, FCCP and Zeenat Safdar, MD, FCCP

* From the Division of Pulmonary-Critical Care Medicine, Baylor College of Medicine, Houston, TX.

Correspondence to: Zeenat Safdar, MD, FCCP, Assistant Professor of Medicine, Baylor College of Medicine, 6620 Main St, Suite 11B, Houston, TX 77030; e-mail: safdar{at}bcm.edu

Abstract

Introduction: Cystic fibrosis (CF) is a common lethal genetic disorder. The aim of this study was to determine the common chest radiograph (CXR) patterns in adult CF, and correlate disease distribution on CXRs with genotype, age, and gender.

Methods: One hundred nine CF patients treated at Baylor Adult Cystic Fibrosis Center were identified. The intake CXR was reviewed and characterized as diffuse bilateral (DB), unilateral, upper lobe (UL), and lower lobe (LL) disease, or relatively normal. Lack of intake CXR, and/or genotype excluded 41 patients from analysis.

Results: Of 68 patients, 38 were homozygous for {Delta}F508 and 30 were heterozygous. Mean age of the population was 30 ± 8 years (± SD) [range, 18 to 48 years]. The most common CXR pattern was DB; 62% had DB, 28% had UL, and 7% had LL predominance. This is in contrast to the UL-predominant CXR pattern commonly described in the pediatric population. In 18 DB patients, archived pediatric films were available, and the average patient age was 15.7 years. DB pattern was present in 16 of 18 CXRs that antedated adult intake CXRs by an average of 12.7 years. Homozygous {Delta}F508 genotype was identified in 56% of patients and did not distinguish radiologic phenotypes. There was no association between radiograph pattern and identified infecting/colonizing organisms and percentage of predicted FEV1.

Conclusions: CF has commonly been reported as an UL disease. However, in this study of adult patients, the common pattern observed was DB. A small subgroup analysis suggests that DB disease was not a pattern of disease evolution but may be present from disease onset.

Key Words: airway • chest radiograph • clinical research • lung function • respiratory care • thoracic radiology






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American College of Chest Physicians.