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ACCP Evidence-Based Guideline Development^*

A Successful and Transparent Approach Addressing Conflict of Interest, Funding, and Patient-Centered Recommendations

^* From the University of Mississippi Medical Center (Dr. Baumann), Jackson, MS, and Immediate Past Chair, ACCP Health and Science Policy Committee; the American College of Chest Physicians (Dr. Lewis), Northbrook, IL; and the Department of Medicine (Dr. Gutterman), Medical College of Wisconsin, Milwaukee, WI, and Chair, ACCP Health and Science Policy Committee. The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Correspondence to: Sandra Zelman Lewis, PhD, American College of Chest Physicians, 3300 Dundee Rd, Northbrook, IL 60062-2348; e-mail: slewis{at}chestnet.org

Abstract

Evidence-based clinical practice guidelines (EBGs) can provide an invaluable distillation of knowledge regarding best practices based on the available evidence. EBGs, providing accurate and useful guidance to best clinical practices, require a rigorous development process. The American College of Chest Physicians (ACCP) has developed a process that embodies transparency, thoroughness, and timeliness, and effective conflict-of-interest management, and it continues to evolve. This process employs a quantitative and rigorous grading of the strength of recommendations and of the quality of evidence that incorporates sensitivity to health-care resource utilization and patient values and preferences. A review of this process is provided to inform the ACCP membership and those wishing to embark on EBG development.

Key Words: clinical practice guidelines • conflict of interest • evidence-based guidelines

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