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High-Resolution Chest CT Findings Do Not Predict the Presence of Pulmonary Hypertension in Advanced Idiopathic Pulmonary Fibrosis^*

^* From the Department of Medicine (Drs. Zisman, Ross, Keane, Belperio, Saggar, and Lynch), Division of Pulmonary and Critical Care Medicine; Department of Medicine (Dr. Karlamangla), Division of Geriatrics; Department of Surgery (Dr. Ardehali), Division of Cardiothoracic Surgery; and Department of Radiology (Dr. Goldin), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.

Correspondence to: David A. Zisman, MD, FCCP, Interstitial Lung Disease Center, David Geffen School of Medicine at UCLA, 37–131 Center for Health Sciences, Los Angeles, CA 90095; e-mail: dzisman{at}mednet.ucla.edu

Abstract

Background: Reliable, noninvasive approaches to the diagnosis of pulmonary hypertension (PH) in patients with idiopathic pulmonary fibrosis (IPF) are needed. We tested the hypothesis that chest CT-determined extent of pulmonary fibrosis and/or main pulmonary artery diameter (MPAD) can be used to identify the presence of PH in patients with advanced IPF.

Methods: Cross-sectional study of 65 patients with advanced IPF and available right-heart catheterization and high-resolution chest CT. An expert radiologist scored ground-glass opacity, lung fibrosis, and honeycombing in the CT images on a scale of 0 to 4. These scores were also summed into a total profusion score. The main pulmonary artery was measured at its widest dimension on the supine full-chest sequence. At this same level, the widest aorta diameter was measured.

Results: Chest CT-determined fibrosis score, ground-glass opacity score, honeycombing score, total profusion score, diameter of the main pulmonary artery, and the ratio of the pulmonary artery to aorta diameter did not differ between those with and without PH. There was no significant correlation between mean pulmonary artery pressure and any of the chest CT-determined measures.

Conclusions: High-resolution chest CT-determined extent of pulmonary fibrosis and/or MPAD cannot be used to screen for PH in advanced IPF patients.

Key Words: diagnosis • high-resolution chest CT hypertension, pulmonary • pressure, pulmonary artery • pulmonary fibrosis

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				H. Chen, T. De Marco, J. A. Golden, M. K. Gould, D. A. Zisman, and A. S. Karlamangla Utility of CT for Predicting Pulmonary Hypertension in Patients With Parenchymal Lung Disease: Similar Results, Different Conclusion? Chest, April 1, 2008; 133(4): 1053 - 1054. [Full Text] [PDF]

				D. A. Zisman, A. S. Karlamangla, S. M. Kawut, O. A. Shlobin, R. Saggar, D. J. Ross, M. I. Schwarz, J. A. Belperio, A. Ardehali, J. P. Lynch III, et al. Validation of a Method To Screen for Pulmonary Hypertension in Advanced Idiopathic Pulmonary Fibrosis Chest, March 1, 2008; 133(3): 640 - 645. [Abstract] [Full Text] [PDF]