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(Chest. 1949;16:633-656.)
© 1949 American College of Chest Physicians

A Preliminary Report on the Use of Para-Amino Salicylic Acid in the Treatment of Pulmonary Tuberculosis

HENRY C. SWEANY M.D., F.C.C.P.1; GEORGE C. TURNER M.D., F.C.C.P.1; MEYER LICHTENSTEIN M.D.1; and SAMSON ENTIN M.D.1

1 The City of Chicago Municipal Tuberculosis Sanitarium Clinical and Research Departments.

P.A.S. therapy was of considerable benefit when used on patients having pulmonary tuberculosis with exudative disease and tension cavities. It appears to have a definite effect on a few cases of chronic fibro-ulcerative tuberculosis, although the majority were not benefited. When used after streptomycin has failed, it improved nearly 50 per cent of the cases treated.

The drug does not appear to produce any marked resistance in tubercle bacilli. It does not seem to possess any permanent toxic effect when properly administered. For these various reasons, therefore, P.A.S. appears to have a definite field of usefulness in the treatment of pulmonary tuberculosis.






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