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(Chest. 1949;16:667-675.)
© 1949 American College of Chest Physicians

The Occurrence of Tubercle Bacilli Resistant to Paminosalicylic Acid (PAS)

ALFRED G. KARLSON D.V.M., Ph.D.1; ANDRE DELAUDE 2; DAVID T. CARR M.D.3; KARL H. PFUETZE M.D., F.C.C.P.4; and WILLIAM H. FELDMAN D.V.M., M.Sc., D.Sc.1

1 Division of Experimental Medicine, Mayo Foundation.
2 Fellow in Experimental Medicine, Mayo Clinic.
3 M.S. in Medicine, Division of Medicine, Mayo Clinic.
4 Medical Director and Superintendent, Mineral Springs Sanatorium, Cannon Falls, Minnesota.

One hundred and two cultures of human-type tubercle bacilli from patients who had not received PAS were found to be resistant to 0.018 mg. of PAS per 100 ml. of egg-yolk agar but not to 0.072 mg. Four cultures were resistant to 0.072 mg. and one to 0.144 mg. per 100 ml. of the medium. Cultures from four of eight patients treated with PAS alone for prolonged periods (90 to 267 days) were able to resist the inhibitory action of PAS at concentrations greatly in excess of that required to inhibit the growth of strains from untreated patients. In a group of 10 patients treated with streptomycin, PAS and promin, only one was found after treatment to have streptomycin-resistant tubercle bacilli and one other had PAS-resistant tubercle bacilli.






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Copyright © 1949 by the American College of Chest Physicians.