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(Chest. 1949;16:867-869.)
© 1949 American College of Chest Physicians

Treatment of Tuberculosis with Promizole: A Clinical Investigation with Matched Controls

H. A. BURNS M.D., F.C.C.P.; W. H. FELDMAN Ph.D.1; H. C. HINSHAW M.D.2; J. A. MYERS M.D., F.C.C.P.3; and K. H. PFUETZE M.D., F.C.C.P.4

1 Mayo Foundation, Rochester, Minnesota.
2 Stanford University Medical School.
3 University of Minnesota Medical School.
4 Mineral Springs Sanatorium, Cannon Falls, Minnesota.

Evidence developed by his study indicated that the severe progressive, potentially fatal type of bnonchopneumonic tuberculosis selected for treatment with promizole did not respond to such medication given under the conditions of this experiment.

It is quite possible that the handicaps imposed were too severe to be overcome. It is also possible that patients with associated mental disease are less likely to respond favorably to therapy than individuals with normal mentality.

Subsequent experience with streptomycin has demonstrated to the satisfaction of this group of investigators that a large percentage of the patients selected for this study would have made at least temporary improvement with streptomycin therapy had this drug been available at that time.






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Copyright © 1949 by the American College of Chest Physicians.