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(Chest. 1951;19:373-386.)
© 1951 American College of Chest Physicians

The Combined Effect of Potassium Iodide and Streptomycin on Far Advanced Chronic Pulmonary Tuberculosis

EDGAR WOODY JR. M.D.1; HOLLIS E. JOHNSON M.D., F.C.C.P.2; ROY C. AVERY M.D.3; and RAYMOND R. CROWE M.D., F.C.C.P.4

1 Research Fellow, American College of Physicians, Davidson County Tuberculosis Sanitarium., The department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
2 Associate Professor of Clinical Medicine, Davidson County Tuberculosis Sanitarium., The department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
3 Associate Professor of Bacteriology, Davidson County Tuberculosis Sanitarium., The department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
4 Instructor in Clinical Medicine and Superintendent, Davidson County Tuberculosis Sanitarium., The department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.

A report has been given of the results of treatment in 58 cases of far advanced chronic pulmonary tuberculosis. Twenty-three patients were treated with one gram of streptomycin daily, while the remaining 35 were given combined treatment consisting of streptomycin and potassium iodide. The gradual emergence of streptomycin resistance was noted after the 60th day in all but three cases in each group. Significant radiographic and nutritional changes were noted infrequently in the control group receiving streptomycin alone. In the group receiving streptomycin and potassium iodide considerable improvement was noted both in chest x-ray film changes and in weight. No evidence was found that potassium iodide is harmful in tuberculosis when administered in conjunction with streptomycin. Statistical analysis suggests that the weight variations are of questionable significance, while the cavity changes appear to be significant. The small cavities in the lungs of five patients receiving streptomycin and potassium iodide closed completely. For this reason it is believed that in selected cases this treatment regimen may avert the need for surgical collapse therapy. In addition, certain far-advanced inoperable cases may be salvaged and rendered more suitable for surgical intervention.






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Copyright © 1951 by the American College of Chest Physicians.