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(Chest. 1951;20:575-587.)
© 1951 American College of Chest Physicians

Intravenous ACTH Therapy in the Treatment of Bronchial Asthma

MAURICE S. SEGAL M.D. F.C.C.P.1 and J. AARON HERSCHFUS M.D.2

1 Clinical Professor of Medicine, Tufts College Medical School; Director, Department of Inhalational Therapy, Boston City Hospital.
2 Research Fellow in Medicine, Tufts College Medical School.

1) Eleven courses of intravenous ACTH by continuous infusion were given to 10 patients with severe bronchial asthma.

2) The total dose ranged between 10 mg. and 210 mg. given over a period of one to nine days.

3) Seven patients obtained excellent remissions lasting up to six weeks. The others obtained partial remissions only. There was no complete therapeutic failure.

4) One patient who demonstrated clinical resistance and eosinophil escape with i.m. ACTH responded promptly to i.v. ACTH.

5) Antibiotics should be administered concomitantly, particularly to those patients with bronchitic manifestations, to combat possible depressed resistance to infection produced by ACTH.






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Copyright © 1951 by the American College of Chest Physicians.