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(Chest. 1952;21:86-101.)
© 1952 American College of Chest Physicians

The Surgical Pathology of Pulmonary Tuberculosis

Mechanism of Cavity Healing as Seen with Streptomycin Therapy

GERTRUDE SILVERMAN M.D.1; ROBERT KLOPSTOCK M.D.1; and GLEN GIBBONS M.D.1

1 The Department of Pathology and Thoracic Surgery of Triboro Hospital, Jamaica, New York.

Surgically removed anatomical units of lung tissue in pulmonary tuberculosis are becoming more abundant. This material, investigated with careful clinical-pathological correlation, will offer a great deal of information concerning the pathogenesis of the disease.

Twenty-two specimens representing lobectomies and segmental resections for pulmonary tuberculosis were reviewed. The pathology of the cavity, its stage of healing, and related tuberculous processes in each specimen, were studied. Salient points that can be deduced are:

1) Cavity "healing" takes place most frequently by the formation of a round focus, with blockage of the draining bronchi.

2) The round focus tends to be large, in part due to the rapid tempo of cavity healing enhanced by streptomycin.

3) This round foci, the most frequent "healed" variant of the tuberculous cavity, is potentially dangerous, and can readily reactivate.






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Copyright © 1952 by the American College of Chest Physicians.