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(Chest. 1952;21:137-145.)
© 1952 American College of Chest Physicians

An Evaluation of the Effect of Khellin on the Pulmonary Circulation in Man

HELEN R. CASH B.S.1 and HENRY A. ZIMMERMAN M.D.1

1 The cardiovascular laboratory, City Hospital, Western Reserve University, Cleveland, Ohio.

1) The effect of khellin on the pulmonary circulation and on cardiac output has been evaluated in five patients with pulmonary hypertension by means of cardiac catheterization. Intracardiac and femoral arterial pressures were recorded and cardiac output and stroke volume were determined before and subsequent to the administration of khellin.

2) Five patients received 200 mg. of khellin intramuscularly, and one of these five was subsequently maintained on oral khellin for six days and recatheterized.

3) No significant alteration from base line studies was noted in pulmonary arterial pressure or in cardiac output.

4) The therapeutic usefulness of khellin in the treatment of chronic cor pulmonale and bronchial asthma is doubtful.






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Copyright © 1952 by the American College of Chest Physicians.