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(Chest. 1952;21:513-520.)
© 1952 American College of Chest Physicians

Deficiencies in Our Knowledge of BCG Vaccine

MILTON I. LEVINE M.D., F.C.C.P.1

1 The New York Hospital-Cornell Medical Center, Department of Pediatrics.

1) No method has been developed for stabilizing the potency of BCG vaccine.

2) No method has been devised for preventing the rapid decline of viable organisms in the freshly prepared vaccine.

3) A marked variation in potency as well as in number of viable organisms exists in similar amounts of BCG from different laboratories.

4) The exact degree of immunity received from BCG and the duration of this immunity are not as yet determined.

5) Adequate knowledge is lacking concerning possible differences in immunizing qualities of the vaccine in different racial groups.

6) The optimal method of BCG vaccination is still open to question.

7) BCG vaccination should not be offered as a substitute for other anti-tuberculosis methods so successfully used in the United States.






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Copyright © 1952 by the American College of Chest Physicians.