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(Chest. 1952;21:521-526.)
© 1952 American College of Chest Physicians

Experience with High Doses of Para-Aminosalicylic Acid in the Treatment of Pulmonary Tuberculosis

SAMUEL PHILLIPS M.D., F.C.C.P.1; JOHN C. LARKIN JR. M.D.1; and WILLARD A. LITZENBERGER M.D.1

1 The Tuberculosis Section, Medical Service, Veterans Administration Medical Teaching Group, Kennedy Hospital, Memphis, Tennessee.

1) High dosages of PAS are possible in most patients able to take smaller doses, but the side-effects are more common and more troublesome.

2) Increased doses of PAS generally lead to increased blood levels of the drug, but there is marked variation from patient to patient.

3) Large doses of PAS seem to bring about decreased blood levels of prothrombin.

4) The results obtained with the use of high doses of PAS, are not impressive as compared to the use of combined therapy.

5) Use of PAS alone gives rise to strains of bacilli resistant to PAS. This may interfere with the use of combined streptomycin and PAS therapy at a later date.






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