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1 Senior Attending, Tuberculosis Service, Los Angeles County General Hospital.
2 Resident Physician, Tuberculosis Service, Los Angeles County General Hospital.
1) Local injection of hyaluronidase is capable of intensifying the reaction to the multiple puncture application of BCG vaccine.
2) The intensification of this reaction apparently has no influence on the persistence of tuberculin skin sensitivity. Its effect on the development of such sensitivity is questionable.
3) Therapeutic value of BCG vaccination cannot be completely ruled out, but appears unlikely.
4) A late flare-up at the site of previously negative tuberculin skin test following BCG vaccination is reported and its possible significance suggested.
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