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(Chest. 1952;22:458-465.)
© 1952 American College of Chest Physicians

A Comparative Study of the Susceptibility of Acid Fast Bacilli to Streptomycin, PAS, Neomycin and 4-Acetylaminobenzaldehyde Thiosemicarbazone

ARTHUR H. K. DJANG M.D.1; EMIL BOGEN M.D., F.C.C.P.2; and DRAKE W. WILL B.S.2

1 Barlow Sanatorium, Los Angeles, California., Department of Infectious Diseases, School of Medicine, University of California at Los Angeles and Western Trudeau Streptomycin Laboratory, Olive View, California.
2 Department of Infectious Diseases, School of Medicine, University of California at Los Angeles and Western Trudeau Streptomycin Laboratory, Olive View, California.

Thirty-seven different strains of acid fast bacilli, E. coli and staph. aureus were used as test organisms against streptomycin, PAS, neomycin and 4-Acetylaminobenzaldehyde thiosemicarbazone.

Human type tubercle bacilli were inhibited by all of the above agents, virulent bovine bacilli by all but PAS, avian bacilli were resistant to all but streptomycin, while BCG and the saprophytic strains were susceptible to streptomycin and neomycin but unaffected by PAS or 4-Acetylaminobenzaldehyde thiosemicarbazone.

These characteristic reaction patterns are useful in the identification and classification of strains of acid fast bacilli.






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Copyright © 1952 by the American College of Chest Physicians.