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(Chest. 1953;23:94-97.)
© 1953 American College of Chest Physicians

Tibione (Amithiozone) in Pulmonary Tuberculosis

H. ORREGO PUELMA M.D., F.C.C.P.; MARIO ZANOLLI GRANELLO M.D.; and ROBERTO OLMEDO CRUZ M.D.1

1 The Hospital Del Salvador, Santiago, Chile.

From these observations we believe that Tibione has some use in the treatment of pulmonary tuberculosis, especially in early and spreading lesions. However, it is not comparable with streptomycin or PAS, which have shown greater activity against tuberculous focci. However, studying the results obtained in our observations we believe that aid which may be obtained with Tibione should not be disregarded.

Its general action on subjective symptomology, weight curve, sedimentation rate, etc., can be considered as sufficiently satisfactory.

Bacillus activity was, in reality, little influenced among our 86 positive cases; only 21 were converted. This result, together with our earlier work with streptomycin emphasizes that chemotherapy to date is only an aid in the treatment of pulmonary tuberculosis.

We should, under no circumstance, postpone administration of classical methods of medical and surgical treatment.






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