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(Chest. 1953;24:591-600.)
© 1953 American College of Chest Physicians

Clinical Observations on Viomycin Sulphate in the Treatment of Tuberculosis

ROBERT L. HACKNEY M.D.1; ERNEST Q. KING M.D.1; EDWARD E. MARSHALL D.Sc.1; K. ALBERT HARDEN M.D.1; and HOWARD M. PAYNE M.D.1

1 The Division of Chronic Chest Diseases of Freedmen's Hospital and Howard University.

1) Viomycin in doses of 2 grams twice weekly combined with 12 grams of PAS daily is of slight toxicity.

2) Tinnitus may be expected to occur. Allergic symptoms have not been a major problem. Auditory nerve damage of a serious degree is not frequent.

3) Streptomycin resistant organisms are affected by viomycin and patients having such organisms improve under intermittent viomycin treatment.

4) Bacterial resistance to viomycin did not develop to a significant degree among patients treated for six months.

5) Clinical and x-ray improvement is more striking in streptomycin-PAS treated patients, however, the effectiveness of viomycin-PAS is definite and demonstrable.

6) The clinical use of viomycin is feasible in the presence of streptomycin resistant organisms, and allergic sensitivity to streptomycin. Its use with newer antimicrobials should be explored.






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Copyright © 1953 by the American College of Chest Physicians.