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(Chest. 1953;24:655-662.)
© 1953 American College of Chest Physicians

Experiences with Tetraethyl Ammonium Chloride in Bronchial Asthma

LLOYD GREGORY M.D.1; MICHEL DAMIANI M.D.2; MARY JOHANSON M.D.2; ANDREW ORMSBY Ph.D.3; and ARTHUR RUSKIN M.D.4

1 The Departments of Internal Medicine and Biochemistry, University of Texas Medical Branch, Galveston, Texas., Resident in Internal Medicine, Captain, M.C., U.S. Army.
2 The Departments of Internal Medicine and Biochemistry, University of Texas Medical Branch, Galveston, Texas.
3 Associate Professor of Biochemistry and Nutrition, The Departments of Internal Medicine and Biochemistry, University of Texas Medical Branch, Galveston, Texas.
4 Associate Professor of Internal Medicine, The Departments of Internal Medicine and Biochemistry, University of Texas Medical Branch, Galveston, Texas.

1) In 20 cases of bronchial asthma the effects of parenteral Etamon were compared with those of epinephrine and aminophylline during mild, severe, and histamine-induced attacks.

2) Parenteral tetraethyl ammonium chloride usually altered the asthmatic state: relief was more frequent than aggravation. Occasional fatalities contraindicate the use of TEA in bronchial asthma as well as in coronary heart disease.

3) The effects of TEA in asthma may be linked to ganglionic blockade, decreased pulmonary vascular resistance and pressure, and epinephrine sensitization. Some favorable effects of Banthine may support the first mode of action. Indirect signs of the intermediation of endogenous hyper-epinephrinemia in TEA action are discussed.






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Copyright © 1953 by the American College of Chest Physicians.