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(Chest. 1954;25:573-579.)
© 1954 American College of Chest Physicians

A Controlled Study of Isoniazid and Iproniazid

M. R. LICHTENSTEIN M.D., F.C.C.P.1 and EDWARD MIZENBERG M.D.2

1 Medical Director, The Municipal Tuberculosis Sanitarium, Chicago, Illinois.
2 Supervising Physician, The Municipal Tuberculosis Sanitarium, Chicago, Illinois.

Experience with isoniazid in pulmonary tuberculosis over a period of 18 months, involving about 500 patients, has indicated that the drug is of approximately the same order of effectiveness as streptomycin and para-aminosalicylic acid. In newly admitted, previously untreated patients, the results have been excellent, about 75 per cent achieving moderate or marked clearing on roentgenograms. Among patients who had persisting disease after considerable streptomycin and para-aminosalicylic acid therapy, isoniazid achieved but little improvement as demonstrated by roentgenograms; however, symptomatic improvement occurred in this group and was maintained in the large majority throughout the period of observation. Spread of disease while on isoniazid was uncommon.

Toxic effects were negligible with isoniazid.

Results with iproniazid were approximately the same as with isoniazid. but toxic effects were common and troublesome.






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Copyright © 1954 by the American College of Chest Physicians.