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(Chest. 1954;26:268-272.)
© 1954 American College of Chest Physicians

Results of the Use of Hydrazide of Isonicotinic Acid in the Therapy of Pulmonary Tuberculosis, Tuberculous Meningitis and Empyemas

N. OECONOMOPOULOS M.D., F.C.C.P.1; C. STEPHANOPOULOS M.D.1; D. LIACACOS M.D.1; E. COSTELETOS M.D.1; A. POLYCHRONIDES M.D.1; A. NASAINAS M.D.1; and TH. TSIMONOS M.D.1

1 The University Clinic of Phthisiology, Sanatorium "Sotiria".

The hydrazide of isonicotinic acid was administered to 144 persons with pulmonary tuberculosis, 48 with meningitis and 18 with empyema.

In doses of 10 milligrams per kilo of body weight, the only undesirable side effect were slight psychic disturbances.

Favorable effects were observed on toxic symptoms of pulmonary tuberculosis and in a large percentage, life was prolonged, but no change was observed in the lesions themselves.

Complete clinical and laboratory recovery occurred in 27 of the 48 cases of meningitis.

Selective favorable effect was noted with healing of tuberculous empyema and of fistulae by oral use of the drug.






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Copyright © 1954 by the American College of Chest Physicians.