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(Chest. 1955;27:44-50.)
© 1955 American College of Chest Physicians

Experience with Pyrazinamide

BENJAMIN P. POTTER M.D., F.C.C.P.1 and SAU FONG CHANG M.D.2

1 Consultant Diseases of the Chest, Allenwood Hospital, N. J. and Visiting Physician, Sea View Hospital, N. Y.
2 Resident Physician, Nassau County Sanatorium, N. Y.

1. Sixty cases were treated with pyrazinamide; 27 with this drug alone and the remainder in combination with streptomycin or PAS.

2. Retrogressive roentgenographic changes were observed in 13 (21.6 per cent). Symptomatic improvement, however, was more frequent and more marked.

3. Roentgenographic improvement appears to depend more on the duration of the disease than on its extent and is more prevalent when pyrazinamide and streptomycin are used together.

4. Toxic effects consist of hepatitis and fatal hemoptyses. Of the former there were eight patients with one death and of the latter eight patients, seven died.

5. In view of the prevalent toxicity of the drug we believe that its use should be discouraged.

6. Conversion of sputum took place in 11 (18.3 per cent).






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Copyright © 1955 by the American College of Chest Physicians.