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(Chest. 1955;27:65-68.)
© 1955 American College of Chest Physicians

Nisentil As an Analgesic in Bronchoscopy

H. W. GIERSON M.D.; LEON S. GOTTLIEB M.D.; and HENRY J. RUBIN M.D.1

1 The Tuberculosis Service, Los Angeles County General Hospital.

1. Alphaprodine was used in 119 bronchoscopies with satisfactory analgesia in 96.6 per cent.

2. Best results were obtained with 30 mg. of the narcotic injected subcutaneously, preceded by sodium pentobarbital, 1frac12 grains, orally.

3. Side effects were minimal, consisting of mild, transient dizziness and/or nausea, occurring 10 or 15 minutes after administration and clearing spontaneously in a few minutes. The retching and/or vomiting encountered with morphine and some synthetic narcotics were singularly absent.

4. When alphaprodine and a barbiturate are used in conjunction a synergistic depression of respiration results.

5. This drug appears to be an acceptable analgesic agent for bronchoscopy. It provides prompt and effective analgesia, has a short duration of action, and leaves a clear sensorium.






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