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(Chest. 1955;27:558-562.)
© 1955 American College of Chest Physicians

Mental Changes Observed in 152 Psychotic and Non-psychotic Patients During INH Medication

RUDOLPH ROSENFELD M.D.1

1 Physician in charge of the tuberculosis unit of the Oregon State Hospital, Salem, Oregon.

One hundred fifty-two patients, suffering from tuberculosis have been observed in regard to mental changes during INH medication of whom 149 had been mentally ill before INH treatment, three developed acute psychosis during INH medication. Of the 149, 17 per cent improved mentally during the treatment course and two of them (1.5 per cent) deteriorated. Three, who had been mentally normal before INH treatment, became so again after discontinuation of the drug, one only after electroshock treatment and another remained in good mental health also after reinstitution of INH. All were observed for a period from two months to two years.






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Copyright © 1955 by the American College of Chest Physicians.