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(Chest. 1956;30:306-314.)
© 1956 American College of Chest Physicians

Some Factors Affecting Isolation of Tubercle Bacilli from Patients Receiving Chemotherapy

EDITH L. DUERR Ph.D.1 and THOMAS C. BLACK M.D., F.C.C.P.2

1 Chief, Microbiology Section, Laboratory Service, Veterans Administration Hospital, Bronx, New York.
2 Chief, Tuberculosis Service, Veterans Administration Hospital.

1. Sputum specimens from a series of patients receiving chemotherapy were collected under specified conditions, and carefully studied to determine factors affecting isolation of tubercle bacilli, as distinct from response to chemotherapy.

2. The period of collection of specimens affected results, in that more positive cultures were obtained from 24 hour than from 48 hour specimens.

3. Those collected after more than two but less than six months of chemotherapy showed significant suppression of growth from some specimens; this was not seen from specimens collected after longer periods of treatment.

4. The drug susceptibility of the organisms appeared to affect results: SM-resistant and PAS-resistant organisms showed little or no suppression; INH-resistant organisms showed some effect, and organisms completely susceptible to all three drugs were most markedly affected.

5. The particular drugs being currently administered showed a definite effect: PAS had the most marked suppressive action, INH some, but less, and SM little or none under the conditions tested.






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Copyright © 1956 by the American College of Chest Physicians.