Chest ACCP Career Connection
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by COHEN, R. V.
Right arrow Articles by ZARAFONETIS, C. J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by COHEN, R. V.
Right arrow Articles by ZARAFONETIS, C. J. D.
(Chest. 1956;30:418-428.)
© 1956 American College of Chest Physicians

Clinical Studies of Various Forms of PAS (With Special Reference to Plasma Concentrations)

ROBERT V. COHEN M.D., F.C.C.P.1; LYNDALL MOLTHAN M.D.1; and CHRIS J. D. ZARAFONETIS M.D.1

1 The Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania; and the Eagleville Sanatorium, Eagleville, Pennsylvania.

Potassium para-aminosalicylate (KPAS) was administered to 120 patients with tuberculosis.

One hundred fifteen (96 per cent) tolerated 12 gm. daily doses of KPAS without difficulty. There were no evidences of potassium toxicity.

Plasma PAS concentration studies revealed that KPAS is more rapidly absorbed and yields significantly higher values than either PAS or NaPAS.

KPAS is ideally suited for use in patients with congestive heart failure, pregnancy, or other situations in which use of the sodium salt is precluded.

The 10 per cent solution of KPAS was used for "desensitizations" of those who had acquired sensitivity reactions to PAS compounds.

It is concluded that KPAS is superior to other forms of PAS.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1956 by the American College of Chest Physicians.