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(Chest. 1956;30:486-498.)
© 1956 American College of Chest Physicians

The Effects of Corticotropin (ACTH) and Cortisone in Fifteen Cases of Pulmonary Tuberculosis

EUGENE J. DES AUTELS M.D., F.C.C.P.1; JAMES R. ZVETINA M.D.1; GEORGE S. BERG M.D.1; JENNINGS FERSHING M.D.1; and SMITH FREEMAN PH.D., M.D.1

1 The Tuberculosis Service and Research Division, Veterans Administration Hospital.

The effects of ACTH and cortisone in 15 cases of pulmonary tuberculosis are presented.

In the cases reported, cortisone was usually harmful and never beneficial; whereas ACTH may have been beneficial in an occasional case, of equivocal effect in some, and probably harmful in the majority.

Contraindications to hormonal therapy in tuberculosis seem to be relative rather than absolute; and, in special circumstances, advantages may out-weigh disadvantages.

When hormonal therapy is mandatory in the presence of tuberculosis, and a choice of either ACTH or cortisone is available, preference should be given to ACTH. Effective antimicrobial therapy must always be given concurrently in an effort to neutralize or minimize the potential ill-effects of hormonal therapy insofar as is possible; and hormonal therapy discontinued in step-wise fashion as rapidly as the patient's condition permits.






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Copyright © 1956 by the American College of Chest Physicians.