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(Chest. 1957;31:169-179.)
© 1957 American College of Chest Physicians

Sputum Cytology in Patients Following Enzyme Aerosol Therapy

LAWRENCE ALAN FARBER M.D.

1. Sputum cytology has afforded a relatively simple but accurate method for diagnosis of bronchogenic carcinoma.

2. Pulmonary enzyme aerosol therapy utilizing trypsin and desoxyribonuclease has been reported upon recently with good clinical results. The effect is digestion and thus thinning of sputum, making expectoration easier.

3. A recent report from San Francisco by S. M. Farber and aasociates demonstrated the appearance of atypical metaplasia following trypsin and trypsin plus dornase aerosol. They exposed 23 patients to dornase aerosol alone and collected sputum smears before, during and after treatment.

4. These slides were examined by the author and the results presented and discussed in this paper. No atypical metaplasia was seen following dornase aerosol.






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Copyright © 1957 by the American College of Chest Physicians.