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(Chest. 1957;32:274-279.)
© 1957 American College of Chest Physicians

The Rising Incidence of Isoniazid Resistance: Its Clinical Significance

JACK REISS M.D., F.C.C.P.1 and SAM M. TOWNSEND M.S.2

1 The Medical Service and Research Laboratories, Veterans Administration Hospital., Chief, Pulmonary Disease Section, Medical Service.
2 The Medical Service and Research Laboratories, Veterans Administration Hospital.

1. In a series of 322 consecutive patients, an incidence of primary resistance to isoniazid of 10 per cent was demonstrated.

2. Newly diagnosed cases of pulmonary tuberculosis respond well to combined drug regime in spite of initial resistance to isoniazid.

3. Patients with chronic cavitary tuberculosis of long duration who are initially resistant to INH may respond well to combined chemotherapy; however, most of them require surgical help to effect an arrest of their disease.

4. Drug resistance has thus far not become a public health problem in newly discovered untreated patients.






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Copyright © 1957 by the American College of Chest Physicians.