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(Chest. 1958;33:261-267.)
© 1958 American College of Chest Physicians

A Preliminary Report on the Safety and Therapeutic Activity of a Salizid INH Derivative

W. E. ROYE M.D., F.C.C.P.1 and G. E. EWART M.D.1

1 The Medical Service, Veterans Administration Hospital.

Salizid, the salicylaldehyde salt of INH, was tried in a series of 18 cases. In a toxicity evaluation doses up to 1600 mg. daily were employed for as long as 10 months. No evidence of neurotoxicity or hepatic damage was obtained from EEG tracings, liver functions tests, or post-mortem examinations. In addition, it is well tolerated in doses of 300 mgm. daily by patients having neurologic disease even with peripheral neuritis resulting from INH. Cases resistant to INH do not respond to larger doses of Salizid. When given in combination with other chemotherapeutic agents, in advanced pulmonary tuberculosis it may be of some benefit. Salizid is an excellent drug and merits further usage in pulmonary tuberculosis because of its safety and chemotherapeutic action in cases of INH sensitive tubercle bacilli.






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