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(Chest. 1959;36:41-42.)
© 1959 American College of Chest Physicians

Comparative Study of Concentrations in the Blood of Para-Aminosalicylic Acid in Tuberculous Patients

LEOPOLDO MOLINARI M.D., F.C.C.P.1 and VITALIANO MANRIQUE M.D.2

1 Chief Physician, Bronchopulmonary Service, Hospital Obrero.
2 Chief Physician, Bronchopulmonary Service, Laboratories of the Hospital Obrero.

1. Sodium salt as well as potassium PAS, in doses of 5.5 grams every eight hours as also pure PAS in doses of 4 grams every eight hours, provide therapeutic levels in plasma for four hours.

2. Therapeutic concentrations in plasma have been maintained for six hours, with 5.5 grams of PAS-K and 4 grams of pure buffered PAS every eight hours.

3. Concentration in plasma surpassed its therapeutic level for eight hours only with administration of pure buffered PAS 4 grams every eight hours.

4. Therapeutic concentrations in blood maintained during the 24 hours could make possible a more effective action of PAS, protecting the associated drugs employed, SM or INH against the resistance of tubercle bacilli.






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Copyright © 1959 by the American College of Chest Physicians.