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(Chest. 1960;37:144-156.)
© 1960 American College of Chest Physicians

Experience with Amphotericin in the Therapy of Histoplasmosis

J. L. YATES M.D., F.C.C.P.1; M. N. ATAY M.D.2; H. V. LANGELUTTIG M.D., F.C.C.P.3; C. A. BRASHER M.D., F.C.C.P.4; and M. L. FURCOLOW M.D., F.C.C.P.5

1 Chief of Medicine, Missouri State Sanatorium.
2 Resident in Pulmonary Diseases, Missouri State Sanatorium.
3 Assistant Chief of Medicine, Missouri State Sanatorium.
4 Superintendent and Medical Director, Missouri State Sanatorium.
5 Chief, Kansas City Field Station, CDC., U.S.P.H.C.

We have reported our experience with the use of Amphotericin B therapy in 29 cases of proved active histoplasmosis, and one strongly suspected case. Our results apparently show that the drug is effective, but is primarily suppressive. Although it is the best therapy available now, there is a real need for further study and development of other antifungal agents which can be used in conjunction with Amphotericin and perhaps other methods of administration of the drug should be studied. Also, in view of the toxic effects, the manufacturers should be encouraged to attempt to purify and obtain the active principle in Amphotericin B.






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